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Published on: December 30, 2025
Thrombotic manifestations in SAPHO syndrome. Review of the literature
Tatiana Elizabeth Carranco-Medina1, Cristina Hidalgo-Calleja2, Ismael Calero-Paniagua1
1Servicio de Reumatología, Hospital Universitario de Salamanca, Salamanca, España; Instituto de investigación biomédica de Salamanca (IBSAL), Salamanca, España.
Abstract:
SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a cluster of osteo-cutaneous manifestations that can lead to serious complications such as thrombosis of the subclavian vein or superior vena cava, mainly in patients with significant inflammatory involvement of the anterior-chest-wall. The objective of this study was to review the cases published in the medical literature related with the presence of thrombotic complications in patients diagnosed with SAPHO syndrome and to try to determine their possible pathogenic mechanism and risk factors. We analyzed 11 published reports of isolated clinical cases or case series, a total of 144 patients, which described a total of 15 cases of venous thrombosis. The clinical characteristics of these patients, evaluated to determine whether they meet the ASAS criteria for axial and peripheral spondyloarthritis, is analyzed the need for early diagnosis and treatment is highlighted.
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