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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

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Canine paroxysmal movement disorders.

Ganokon Urkasemsin¹, Natasha J Olby²

¹Department of Pre-Clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, 999 Phuttamonthon Sai 4 Road, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand.

The Veterinary Clinics of North America. Small Animal Practice

|December 3, 2014

Summary

This summary is machine-generated.

Episodic Falling in Cavalier King Charles spaniels is caused by a brevican (BCAN) gene mutation. Understanding these genetic causes improves diagnosis and treatment for canine movement disorders.

Keywords:

Episodic falling Episodic movement disorders Hyperkinetic episode Hypertonicity Paroxysmal dyskinesia Scottie cramp

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Area of Science:

Neurology
Genetics
Veterinary Medicine

Background:

Paroxysmal dyskinesias are episodic movement disorders originating in the central nervous system.
These disorders are characterized by muscle hypertonicity and involuntary movements, distinct from seizure disorders due to preserved consciousness and normal electroencephalography.
Human paroxysmal dyskinesias are classified into three groups based on therapeutic responses.

Purpose of the Study:

To identify the genetic cause of Episodic Falling in Cavalier King Charles spaniels.
To enhance the understanding of canine movement disorders.

Main Methods:

Genetic analysis to identify mutations.
Characterization of the identified gene mutation.

Main Results:

A mutation in the brevican (BCAN) gene was identified as the cause of Episodic Falling.
This finding links a specific gene to a canine movement disorder.

Conclusions:

The BCAN gene mutation is responsible for Episodic Falling in Cavalier King Charles spaniels.
Further genetic research will improve the identification and treatment of canine dyskinesias.