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An acute cough-specific quality-of-life questionnaire for children: Development and validation
Sophie Anderson-James1, Peter A Newcombe2, Julie M Marchant1
1Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia.
The Journal of Allergy and Clinical Immunology
|December 3, 2014
Summary
A new Parent-proxy Children's Acute Cough-specific Quality-of-Life (PAC-QoL) questionnaire was developed and validated. This 16-item tool reliably measures quality of life in children with acute cough.
Area of Science:
- Pediatric Health Research
- Clinical Outcomes Assessment
- Quality of Life Measurement
Background:
- Patient-relevant outcome measures, particularly quality-of-life (QoL) tools, are crucial for high-quality clinical research.
- Currently, a validated questionnaire specifically for children's acute cough-related QoL is unavailable.
Purpose of the Study:
- To develop and validate the Parent-proxy Children's Acute Cough-specific Quality-of-Life (PAC-QoL) questionnaire.
- To establish a reliable and valid tool for assessing QoL in pediatric acute cough.
Main Methods:
- A 48-item PAC-QoL was initially developed using focus groups and subsequently reduced to 16 items via the clinical impact method.
- Parents of 155 children with acute cough (<2 weeks) completed the PAC-QoL, cough scores, and other validated questionnaires (SF-8, STAI, DASS21) at enrollment and on days 3 and 14.
Main Results:
- The 16-item PAC-QoL demonstrated high internal consistency (Cronbach α = 0.95).
- Evidence of repeatability and criterion validity was established through significant correlations with other health measures (SF-8, STAI, DASS21).
- The PAC-QoL was sensitive to changes over time, correlating significantly with changes in cough scores (P < .001).
Conclusions:
- The 16-item PAC-QoL is a reliable and valid instrument for assessing acute cough-specific QoL in children.
- This questionnaire effectively measures QoL at a specific time point and captures changes in QoL over the course of acute cough.
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