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Matrix metalloproteinase 10 is associated with disease severity and mortality in patients with peripheral arterial

Esther Martinez-Aguilar1, Violeta Gomez-Rodriguez2, Josune Orbe2

  • 1Department of Vascular Surgery, Complejo Hospitalario de Navarra, Pamplona, Spain.

Journal of Vascular Surgery
|December 3, 2014
PubMed
Abstract

Insights

Matrix metalloproteinase-10 (MMP-10) is elevated in peripheral arterial disease (PAD) patients, correlating with disease severity. Higher MMP-10 levels predict increased mortality risk in PAD patients, highlighting its prognostic value.

Area of Science:

  • Vascular Biology
  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Peripheral arterial disease (PAD) is linked to significant cardiovascular morbidity and mortality.
  • Matrix metalloproteinases (MMPs), particularly MMP-10 (stromelysin-2), are implicated in vascular remodeling and atherosclerosis.
  • Understanding MMP-10's role in PAD progression and prognosis is crucial for patient outcomes.

Purpose of the Study:

  • To analyze matrix metalloproteinase-10 (MMP-10) levels in peripheral arterial disease (PAD) patients.
  • To correlate MMP-10 levels with PAD disease severity and cardiovascular (CV) risk factors.
  • To evaluate the prognostic significance of MMP-10 for CV events and mortality in PAD.

Main Methods:

  • MMP-10 levels were quantified using enzyme-linked immunosorbent assay (ELISA).
  • The study included 187 PAD patients and 200 sex-matched healthy controls.
  • Follow-up was conducted over 2 years to assess CV events and mortality.

Main Results:

  • PAD patients exhibited significantly higher MMP-10 levels (946 ± 473 pg/mL) compared to controls (702 ± 326 pg/mL).
  • Critical limb ischemia patients showed elevated MMP-10 compared to intermittent claudication patients (1086 ± 478 pg/mL vs. 822 ± 436 pg/mL).
  • Higher MMP-10 tertiles were associated with increased all-cause and CV mortality (P < .03).

Conclusions:

  • Matrix metalloproteinase-10 (MMP-10) is significantly associated with the severity of peripheral arterial disease (PAD).
  • Elevated MMP-10 levels serve as a predictor of poor prognosis and increased mortality in PAD patients.
  • MMP-10 warrants further investigation as a potential therapeutic target and prognostic biomarker in PAD.

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