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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Relationship between kidney disease and endothelial function in peripheral artery disease
Karen C Chong1, Christopher D Owens2, Meyeon Park3
1Division of Vascular and Endovascular Surgery, University of California, San Francisco, Calif; VIPERx Laboratory, University of California, San Francisco, Calif.
Journal of Vascular Surgery
|December 3, 2014
Summary
Decreased kidney function is linked to endothelial dysfunction in peripheral artery disease (PAD) patients. This finding highlights the importance of assessing kidney health in PAD management.
Area of Science:
- Vascular Medicine
- Nephrology
- Cardiology
Background:
- Peripheral artery disease (PAD) is associated with impaired endothelial function (EF).
- Poor EF correlates with reduced functional status and increased morbidity/mortality in PAD patients.
- Identifying factors linked to poor EF in PAD is crucial for patient outcomes.
Purpose of the Study:
- To investigate the association between kidney function and endothelial function in patients with PAD.
- To test the hypothesis that decreased kidney function is linked to impaired EF in PAD.
Main Methods:
- Cross-sectional study of 97 PAD patients from a vascular surgery clinic.
- Endothelial function assessed via brachial artery flow-mediated vasodilation.
- Kidney function measured by estimated glomerular filtration rate (eGFR).
- Linear and multivariable regression analyses were performed.
Main Results:
- A significant association was found between kidney function and EF (P = .001).
- After multivariable adjustment, eGFR remained significantly associated with EF (P = .033).
- The study cohort had high rates of comorbidities including hypertension and dyslipidemia.
Conclusions:
- Decreased kidney function is associated with endothelial dysfunction in PAD patients.
- Further research is needed to understand the impact of kidney function on PAD progression.
- The role of endothelial dysfunction in the kidney-PAD relationship requires further investigation.
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