Related Experiment Video
Updated: Apr 20, 2026
Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
Published on: December 6, 2024
Functional assessment of coronary artery disease by intravascular ultrasound and computational fluid dynamics
Sebastián Carrizo1, Xinzhou Xie2, Rafael Peinado-Peinado3
1Hemodynamics and Interventional Cardiology Unit, Department of Cardiology, University Hospital La Paz, Madrid, Spain.
Abstract:
Clinical trials have shown that functional assessment of coronary stenosis by fractional flow reserve (FFR) improves clinical outcomes. Intravascular ultrasound (IVUS) complements conventional angiography, and is a powerful tool to assess atherosclerotic plaques and to guide percutaneous coronary intervention (PCI). Computational fluid dynamics (CFD) simulation represents a novel method for the functional assessment of coronary flow. A CFD simulation can be calculated from the data normally acquired by IVUS images. A case of coronary heart disease studied with FFR and IVUS, before and after PCI, is presented. A three-dimensional model was constructed based on IVUS images, to which CFD was applied. A discussion of the literature concerning the clinical utility of CFD simulation is provided.
