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Updated: Apr 20, 2026

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Editorial: cell movement.

S Detchokul¹, A G Frauman

¹Clinical Pharmacology and Therapeutics Unit, Department of Medicine, The University of Melbourne, Heidelberg, VIC, Australia.

British Journal of Pharmacology

|December 3, 2014

Summary

Cell migration, crucial for health and disease, is explored for therapeutic targets. Understanding cytoskeletal dynamics and microenvironment sensors offers new strategies for treating cancer metastasis and inflammation.

Area of Science:

Cellular biology
Pathophysiology

Background:

Cell movement is vital in normal physiology and disease.
Aberrant cell migration underlies cancer metastasis, autoimmune diseases, and inflammation.

Discussion:

This themed issue focuses on controlling cellular cytoskeletal dynamics and microenvironment sensors.
Novel therapeutic strategies targeting cell migration are discussed.

Key Insights:

Emerging roles of tetraspanins, phosphoinositides, transient receptor potential cation channels, stromal interaction molecules, and calcium release-activated calcium modulators in cell migration.
Understanding these regulatory factors is key to developing new treatments.

Outlook:

Targeting aberrant cell migration has significant therapeutic implications for common human diseases.

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Last Updated: Apr 20, 2026

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Study of Cell Migration in Microfabricated Channels

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

Further research into regulatory factors will advance therapeutic interventions.