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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Risk factors associated with death in patients with severe respiratory syncytial virus infection

Yen-I Lee1, Chun-Chih Peng2, Nan-Chang Chiu3

  • 1Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|December 3, 2014
PubMed

Insights

Severe respiratory syncytial virus (RSV) infections pose a significant risk, especially for children with Down

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Respiratory syncytial virus (RSV) is a leading cause of viral respiratory infections in children.
  • Severe RSV infections necessitate intensive care, highlighting the need to understand associated risk factors for mortality.

Purpose of the Study:

  • To describe the clinical features of severe RSV infections in children.
  • To identify risk factors associated with death in pediatric patients with severe RSV infection.

Main Methods:

  • Retrospective analysis of 186 pediatric intensive care unit (PICU) patients diagnosed with RSV lower respiratory tract infection (July 2001-June 2010).
  • Inclusion of demographic and medical variables, with a focus on underlying conditions and outcomes.
  • Multivariate analysis to determine significant predictors of mortality.

Main Results:

  • The study included 186 RSV-positive children, with 134 having at least one comorbidity (e.g., prematurity, neurological disease).
  • Ten patients died, all with comorbidities. Key risk factors for death included Down's syndrome (OR 7.20) and nosocomial RSV infection (OR 4.46).

Conclusions:

  • Down's syndrome and hospital-acquired (nosocomial) RSV infection are significant risk factors for mortality in severe pediatric RSV cases.
  • Clinical vigilance for these conditions is crucial for improving outcomes in severe RSV infections.
Abstract

Keywords:
Down's syndromemortalitynosocomial infectionrespiratory syncytial virusrisk factors

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