Lack of effect of GR43175 on peripheral arteries in man

In a double-blind, placebo-controlled crossover study in eight male volunteers, toe-arm systolic gradients, measured with strain-gauge plethysmography, were measured for 4 h after 2 mg intravenous GR43175 or placebo. No changes were observed, indicating that GR43175 is without significant vasoconstrictor effect on peripheral arteries in man.