Related Experiment Video
Updated: Apr 20, 2026
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
[Debut of Leber's hereditary optic neuropathy. Macular segmentation analysis using optical coherence tomography]
E Santos-Bueso1, A Asorey-García1, J Porta-Etessam2
1Unidad de Neurooftalmología, Servicio de Oftalmología, Hospital Clínico San Carlos, Madrid, España. RETICS, Instituto de Salud Carlos III, Red Temática de Investigación Cooperativa, Patología ocular del envejecimiento, calidad visual y calidad de vida, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.
Case Report:
Two clinical cases are presented of two family relatives newly diagnosed with Leber hereditary optic neuropathy (LHON) and G11778A mutation analysis by optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, California, USA) layer peripapillary fibers retina (RNFL) and ganglion cell and internal plexiform layers (GCL/IPL) using macular segmentation.
Discussion:
The analysis of the macula by OCT segmentation (version 6.0 Cirrus OCT) allows the GCL/IPL to be evaluated without the interindividual variability of peripapillary RNFL distribution or the presence of edema of the optic disc. When an analysis of the peripapillary RNFL, it does not provide information on this neuronal damage, which itself is evidence in the study of GCL/IPL.
