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Intraventricular hemorrhage as a comorbid factor for intestinal obstruction in very low-birthweight infants

Chieko Hisamatsu1, Ichiro Morioka2, Kiyomi Matsuo2

  • 1Division of Pediatric Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|December 3, 2014
PubMed

Insights

Intraventricular hemorrhage (IVH) is a significant factor associated with intestinal obstruction (IO) in very low-birthweight infants (VLBWI). This finding highlights the importance of monitoring for IO in VLBWI with IVH.

Area of Science:

  • Neonatal Medicine
  • Pediatric Surgery
  • Clinical Research

Background:

  • Very low-birthweight infants (VLBWI) are susceptible to intestinal obstruction (IO) due to immature gastrointestinal systems and perinatal complications.
  • Understanding comorbid factors is crucial for managing IO in this vulnerable population.

Purpose of the Study:

  • To identify clinical comorbid factors associated with intestinal obstruction (IO) in very low-birthweight infants (VLBWI).

Main Methods:

  • Retrospective review of clinical data from 160 VLBWI admitted between 2006-2011.
  • Patients categorized into IO (n=62) and non-IO (n=98) groups based on bile excretion within 30 days post-birth.
  • Statistical analysis to determine the relationship between clinical factors and IO incidence.

Main Results:

  • Univariate analysis revealed associations between IO and gestational age, birthweight, chronic lung disease, patent ductus arteriosus, intraventricular hemorrhage (IVH), retinopathy of prematurity, and postnatal treatments (mechanical ventilation, catecholamines, steroids, sedatives).
  • Multivariate analysis identified intraventricular hemorrhage (IVH) as the sole factor strongly associated with IO (OR, 4.74; P < 0.01).

Conclusions:

  • Intraventricular hemorrhage (IVH) is a significant comorbid factor contributing to intestinal obstruction (IO) in very low-birthweight infants (VLBWI).
Abstract

Keywords:
comorbid factorintestinal obstructionintraventricular hemorrhagevery low-birthweight infant

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