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An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
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Epigenomic regulation of host-microbiota interactions
Theresa Alenghat1, David Artis2
1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Trends in Immunology
|December 3, 2014
Summary
Mammals and their gut microbiota communicate via epigenomic modifications. Histone deacetylases (HDACs) are key regulators in this host-microbiota interaction, influencing health and disease.
Area of Science:
- Microbiology
- Epigenetics
- Immunology
Background:
- The gastrointestinal tract hosts trillions of commensal microorganisms that influence host health.
- Mechanisms by which mammals recognize microbial signals and maintain homeostasis are not fully understood.
- Epigenomic modifications are crucial for adapting cellular transcription to environmental cues.
Purpose of the Study:
- To review recent advances in the interplay between the mammalian microbiota and epigenomic pathways.
- To highlight the role of histone deacetylases (HDACs) in host-microbiota interactions.
Main Methods:
- Literature review of recent scientific findings.
- Analysis of epigenomic mechanisms in host-microbiota communication.
Main Results:
- Epigenomic modifications play a significant role in the dynamic relationship between mammals and their microbiota.
- Emerging evidence points to histone deacetylases (HDACs) as central orchestrators of host-microbiota interactions.
Conclusions:
- Understanding host-microbiota epigenomic crosstalk is critical for comprehending health and disease.
- HDACs represent a key molecular target for modulating host responses to the gut microbiota.
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