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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Chronic kidney disease and stroke

Nada El Husseini1, Omran Kaskar1, Larry B Goldstein1

  • 1Department of Neurology, Duke University Medical Center, Durham, NC; and Department of Neurology, Wake Forest University Baptist Medical Center, Winston-Salem, NC.

Advances in Chronic Kidney Disease
|December 3, 2014
PubMed

Insights

Chronic kidney disease (CKD) increases stroke risk through mechanisms like platelet dysfunction and inflammation. Managing CKD is crucial for improving stroke outcomes and prevention.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiology

Background:

  • Chronic kidney disease (CKD) is a significant risk factor for cerebrovascular events, including both ischemic and hemorrhagic strokes.
  • CKD contributes to elevated stroke risk via multiple pathophysiological pathways such as platelet dysfunction, coagulation abnormalities, endothelial dysfunction, and inflammation.
  • The presence of CKD can also alter the efficacy and safety of stroke treatments and preventive strategies.

Purpose of the Study:

  • To review the epidemiological links between CKD and stroke.
  • To elucidate the pathophysiological mechanisms connecting CKD and stroke.
  • To examine the impact of CKD on stroke outcomes and treatment.

Main Methods:

  • Literature review focusing on epidemiological data.
  • Analysis of pathophysiological mechanisms linking CKD and stroke.
  • Evaluation of studies on CKD's influence on stroke treatment and outcomes.

Main Results:

  • CKD is strongly associated with a higher incidence of both ischemic and hemorrhagic stroke.
  • Key CKD-associated mechanisms contributing to stroke risk include platelet dysfunction, coagulation disorders, endothelial dysfunction, inflammation, and atrial fibrillation.
  • CKD complicates acute stroke management and secondary prevention strategies.

Conclusions:

  • CKD significantly elevates cerebrovascular risk through various biological pathways.
  • Understanding these links is essential for effective stroke prevention and management in CKD patients.
  • Interdisciplinary care involving nephrologists, neurologists, and other specialists is recommended to improve patient outcomes.

Keywords:
AlteplaseChronic kidney diseaseStrokeStroke preventionThrombolysis

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