Related Experiment Video
Updated: Apr 20, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
Transcatheter pulmonary valvulation: current indications and available devices
Sebastien Hascoët1, Philippe Acar2, Younes Boudjemline3
1Groupe de cathétérisme interventionnel pédiatrique et congénital, filiale de cardiologie pédiatrique et congénitale de la Société française de cardiologie, France; M3C CHU de Toulouse, Paediatric and Congenital Cardiology, Children's Hospital, Paul-Sabatier University, Toulouse, France; Inserm UMR 1048, équipe 8 - I2MC - Institut des Maladies Métaboliques et Cardiovasculaires, Paul-Sabatier University, Toulouse, France; CHU de Toulouse, department of cardiology, Rangueil Hospital, Paul-Sabatier University, Toulouse, France.
Transcatheter pulmonary valve implantation using the Melody valve offers an effective alternative to open-heart surgery. This review details current uses, devices, and clinical outcomes for this minimally invasive procedure.
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomedical Engineering
Background:
- The Melody valve, first implanted in 2000, has become a globally utilized device.
- It serves as a less invasive alternative to traditional open-heart surgery for pulmonary valve replacement.
- Dysfunctional right ventricle to pulmonary artery conduits are a primary indication.
Purpose of the Study:
- To provide a comprehensive review of percutaneous pulmonary valve implantation (PPVI).
- To outline the current clinical indications for PPVI.
- To discuss the devices used and their associated clinical results.
Main Methods:
- Literature review of studies on transcatheter pulmonary valve implantation.
- Analysis of current indications for the Melody valve and similar devices.
- Synthesis of reported clinical outcomes and results.
Main Results:
- The Melody valve is a widely adopted technology for pulmonary valve replacement.
- PPVI demonstrates efficacy as an alternative to surgery.
- Data on indications, devices, and clinical outcomes are synthesized.
Conclusions:
- Percutaneous pulmonary valve implantation is an established and effective treatment modality.
- The Melody valve represents a significant advancement in cardiac interventions.
- Continued review of indications and outcomes is essential for optimizing patient care.
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