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Anti-asthmatic prescription variability in children according to age

I Casares-Alonso1, A Cano-Garcinuño2, A Blanco-Quirós3

  • 1Venta de Baños Health Centre, Regional Health Service, Castilla y León, Palencia, Spain.

Allergologia Et Immunopathologia
|December 3, 2014
PubMed

Insights

Spanish children under four years old were frequently prescribed anti-asthmatic medications, with usage patterns not aligning with asthma guidelines. Prescribed daily doses (PDHD) proved more accurate than defined daily doses (DHD) for measuring consumption.

Area of Science:

  • Pediatric pharmacology
  • Respiratory medicine
  • Public health

Background:

  • Limited research exists on anti-asthmatic agent consumption in the Spanish pediatric population.
  • This study addresses the gap by examining anti-asthmatic drug prescription patterns in children.

Purpose of the Study:

  • To describe anti-asthmatic drug prescription patterns in the pediatric population of a Spanish region.
  • To utilize prescribed daily doses (PDHD) as a unit of measurement for consumption.

Main Methods:

  • Analysis of R03 therapeutic subgroup (anti-asthmatic agents) prescriptions for children under 14.
  • Data collected from the Public Health System of Castilla y León between 2005 and 2010.
  • Consumption measured in PDHD and compared with defined daily doses per thousand inhabitants per day (DHD).

Main Results:

  • Over 394,000 anti-asthmatic prescriptions were issued.
  • Most common: bronchodilators, leukotriene receptor antagonists, inhaled corticosteroids (ICS), and ICS/long-acting β2-adrenergics combinations.
  • Highest bronchodilator use in infants under 12 months; montelukast and single ICS prominent at one year.

Conclusions:

  • Children under four years received high anti-asthmatic prescriptions between 2005-2010.
  • Maintenance therapy use was inconsistent with asthma guideline recommendations.
  • PDHD is a more precise measure of consumption than DHD, particularly for young children.
Abstract

Keywords:
Anti-asthmatic agentsChildhood asthmaDefined daily doseDrug utilisation studiesPharmacoepidemiologyPrescribed daily dose

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