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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

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Related Experiment Video

Updated: Apr 20, 2026

Generating Genetically Modified Plasmodium berghei Sporozoites

Generating Genetically Modified Plasmodium berghei Sporozoites

Published on: May 5, 2023

Gene-therapy for malaria prevention.

Mauricio M Rodrigues¹, Irene S Soares²

¹Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo, São Paulo, SP, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, SP, Brazil.

Trends in Parasitology

|December 3, 2014

Summary

This summary is machine-generated.

New vectored immunoprophylaxis (VIP) offers a novel way to prevent malaria. This approach uses genetically modified cells to produce antibodies, providing an alternative to traditional malaria vaccines.

Keywords:

gene therapy immune-prophylaxis malaria prevention

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Area of Science:

Immunology
Parasitology
Biotechnology

Background:

Limited tools and eradication challenges in malaria prevention necessitate novel strategies.
Vaccine development has been the primary focus for malaria immunoprophylaxis.
Existing methods face challenges in achieving complete disease eradication.

Purpose of the Study:

To introduce and describe vectored immunoprophylaxis (VIP) as an alternative malaria prevention strategy.
To highlight the potential of VIP in generating protective immunity against malaria.
To explore a new avenue for combating malaria beyond conventional vaccines.

Main Methods:

Genetically transducing host cells to express therapeutic antibodies.
Utilizing host cellular machinery for antibody assembly and secretion.
Developing a platform for sustained antibody production for malaria prevention.

Main Results:

Vectored immunoprophylaxis enables host cells to produce and secrete antibodies.
These antibodies are designed to neutralize malaria parasite infectivity.
VIP presents a potential method for preventing malaria disease.

Conclusions:

Vectored immunoprophylaxis (VIP) is a promising alternative strategy for malaria prevention.
This approach leverages host cells for antibody production, offering a new immunoprophylaxis method.
VIP could significantly impact malaria control efforts by providing a novel preventative measure.