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Updated: Apr 20, 2026

Generating Genetically Modified Plasmodium berghei Sporozoites
Published on: May 5, 2023
Gene-therapy for malaria prevention
Mauricio M Rodrigues1, Irene S Soares2
1Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo, São Paulo, SP, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, SP, Brazil.
Abstract:
The limited number of tools for malaria prevention and the inability to eradicate the disease have required large investments in vaccine development, as vaccines have been the only foreseeable type of immunoprophylaxis against malaria. An alternative strategy named vectored immunoprophylaxis (VIP) now would allow genetically transduced host cells to assemble and secrete antibodies that neutralize the infectivity of the malaria parasite and prevent disease.
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