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Depression in multiple sclerosis.

S Mrabet1, N Ben Ali1, M Kchaou1

  • 1Neurology department, Charles-Nicolle Hospital, boulevard du 9 Avril 1006, Tunis, Tunisia.

Revue Neurologique
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Depression is common in multiple sclerosis (MS), affecting 65% of patients. This mood disorder may stem from brain damage or genetic factors, impacting quality of life.

Keywords:
DepressionDépressionMood disordersMultiple sclerosisQuality of lifeQualité de vieSclérose en plaquesTroubles de l’humeur

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Area of Science:

  • Neurology
  • Neuroimmunology
  • Psychiatry

Background:

  • Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease.
  • Depression is a prevalent comorbidity in MS patients, significantly impacting their quality of life.

Purpose of the Study:

  • To determine the prevalence of depression in MS patients.
  • To investigate the relationship between disease severity, depression onset, and neuroimaging findings in MS.

Main Methods:

  • Study included 50 MS patients (aged 20-50) from 2008-2012.
  • Evaluations comprised neuropsychological assessment, physical examination with Expanded Disability Status Scale (EDSS), and Magnetic Resonance Imaging (MRI).

Main Results:

  • The prevalence of depression among MS patients in this study was 65%.
  • Approximately 10% of patients had co-occurring psychiatric disorders.
  • Depression onset varied, appearing either initially or later in the disease course, suggesting potential links to disease processes or functional disability.

Conclusions:

  • Depression is a potential manifestation of MS, possibly linked to demyelinating brain damage or genetic predisposition.
  • The association between MS and depression may not always correlate directly with disease severity.
  • A fortuitous occurrence of depression in MS patients cannot be ruled out.