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Maternal immunization with pneumococcal 9-valent conjugate vaccine and early infant otitis media

Kathleen A Daly1, G Scott Giebink2, Bruce R Lindgren3

  • 1Department of Otolaryngology, University of Minnesota Medical School, Minneapolis, MN, USA.

Vaccine
|December 3, 2014
PubMed

Insights

Maternal immunization with a 9-valent pneumococcal conjugate vaccine (PCV-9) did not prevent infant otitis media (OM). Instead, PCV-9 vaccination during pregnancy may increase infants

Area of Science:

  • Immunology
  • Pediatrics
  • Vaccinology

Background:

  • Otitis media (OM) is a common childhood illness.
  • Preventing infant OM is a significant public health goal.
  • Maternal vaccination is being explored as a strategy to protect infants.

Purpose of the Study:

  • To evaluate the efficacy of maternal immunization with a 9-valent pneumococcal conjugate vaccine (PCV-9) in preventing early-onset infant otitis media (OM).

Main Methods:

  • A randomized controlled trial was conducted where pregnant women received either PCV-9 or placebo in their last trimester.
  • All infants were subsequently vaccinated with Prevnar®.
  • Infant OM incidence was monitored through clinic and adverse event records.

Main Results:

  • Infant OM rates were similar between the PCV-9 and placebo groups at 6 and 12 months.
  • Maternal PCV-9 immunization was associated with an increased risk of acute OM in the first 6 months.
  • Infant antibody responses to vaccine serotypes were decreased, potentially due to maternal antibodies.

Conclusions:

  • Maternal immunization with PCV-9 did not reduce infant OM rates.
  • This strategy may increase the risk of OM and alter infant immune responses to pneumococcal vaccines.
  • Further research is needed to understand the mechanisms behind these findings.

Keywords:
Maternal immunizationOtitis mediaPneumococcal antibodiesPneumococcus

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