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Updated: Apr 20, 2026
Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography
Published on: August 20, 2018
An optimal initial tension for rat basilar artery in wire myography
Xue Xiao1, Na-Na Ping1, Sen Li1
1Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Aims:
The aim of the present study was to determine the optimal initial tension for the rat basilar artery when using wire myography.
Methods:
Rat basilar arteries were mounted in myograph baths. A normalization procedure was performed. K(+)-rich (60mM) buffer solution-induced tension was measured in different initial tensions.
Results:
The initial tension of the basilar artery increased from 0.47 to 2.68mN/mm. Contractile tension was also elevated along with the initial tension. When the initial tension reached 1.63mN/mm, K(+)-induced contractile tension of basilar artery achieved its maximum. Thereafter, contractile tension declined as initial tension increased. The duration of equilibration time did not affect K(+)-induced contractile tension.
Conclusion:
The optimal initial tension is 1.63±0.01mN/mm in rat basilar arteries when using wire myography.
