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Updated: Apr 20, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
Published on: August 14, 2019
A case of Alzheimer's disease following mild traumatic brain injury
Amane Tateno1, Takeshi Sakayori1, Yuichi Takizawa1
1Department of Neuropsychiatry, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
Objective:
To report a case of Alzheimer's disease (AD) following mild traumatic brain injury (TBI).
Method:
Case report.
Results:
We report the time course of AD following mild TBI with evidence of AD pathology. A patient complained of minor memory disturbance 6 months after TBI and was diagnosed with mild cognitive impairment 1.5 years after TBI, and she was finally diagnosed as probable AD 4 years after TBI. Amyloid PET revealed brain accumulation of beta-amyloid at a pathological AD level.
Conclusion:
Our case well illustrated how TBI can accelerate the AD process. Clinicians should carefully follow up patients with persistent cognitive impairment after TBI.
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