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α-Synuclein amino terminus regulates mitochondrial membrane permeability

Jiamei Shen1, Tingting Du1, Xue Wang1

  • 1Center for Parkinson׳s Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Department of Neurobiology Capital Medical University, Beijing 100069, China.

Brain Research
|December 3, 2014
PubMed
Summary

The N terminus of alpha-synuclein (α-Syn/N) triggers mitochondrial dysfunction and cell death in Parkinson's disease models. Inhibiting the adenine nucleotide translocator partially reversed these toxic effects.

Keywords:
Mitochondrial membrane permeabilityParkinson׳s diseaseReactive oxygen speciesα-Synucleinα-Synuclein N terminus

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