Related Experiment Video For DNAJC6
Updated: Apr 20, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
DNAJC6 promotes hepatocellular carcinoma progression through induction of epithelial-mesenchymal transition
Tao Yang1, Xiao-Na Li2, Xing-Guang Li3
1Hepatobiliary Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang 050011, China.
Abstract:
Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with hepatocellular carcinoma (HCC) development and progression. DNAJC6 (DNA/HSP40 homolog subfamily C member 6) encodes auxilin, which is responsible for juvenile Parkinsonism with phenotypic variability. However, the role of DNAJC6 in HCC development and progression is limited. Here, we report that DNAJC6 is up-regulated in HCC tissues and up-regulation of DNAJC6 expression predicts poor outcome in patients with HCC. Furthermore, overexpression of DNAJC6 enhances the ability for acquisition of mesenchymal traits, enhanced cell proliferation and invasion. DNAJC6 positively regulated expression of EMT-related transcription factor, also activating transforming growth factor β (TGF-β) pathway to contribute to EMT. Our findings demonstrated an important function of DNAJC6 in the progression of HCC by induction of EMT, and they implicate DNAJC6 as a marker of poor outcome in HCC.
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