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Urinary Bladder01:23

Urinary Bladder

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Bladder tissue engineering: a literature review.

Ornella Lam Van Ba1, Shachar Aharony1, Oleg Loutochin1

  • 1Department of Urology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

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Bladder tissue engineering offers a promising alternative to traditional bowel grafting for bladder reconstruction, potentially reducing adverse effects and long-term costs. Further research is needed before clinical trials can commence.

Keywords:
BiomaterialBladderBladder reconstructionScaffoldTissue engineering

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Urology

Background:

  • Bladder reconstruction, often for bladder cancer or neurogenic bladder, traditionally uses bowel segments for augmentation cystoplasty or neo-bladder creation.
  • While effective, bowel grafting carries significant short- and long-term adverse effects, highlighting the need for alternative solutions.

Purpose of the Study:

  • To review recent advancements in bladder tissue engineering as a potential alternative to bowel grafting.
  • To forecast characteristics of efficient and safe bladder biomaterials for reconstruction.

Main Methods:

  • Review of recently published articles on bladder tissue engineering.
  • Analysis of progress in biomaterial development and stem cell research for bladder regeneration.

Main Results:

  • Significant progress has been made in developing novel biomaterials for bladder tissue replacement.
  • Research is advancing in understanding the role of stem cells in bladder scaffold integration and tissue regeneration.

Conclusions:

  • Bladder tissue engineering shows promise for reducing morbidity and long-term costs associated with bladder reconstruction.
  • Careful assessment of native bladder traits, urine interaction, and specific indications is crucial before clinical trials.
  • Despite challenges, bladder tissue engineering techniques hold potential for significant clinical benefits.