Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination01:51

Determination

21.5K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
21.5K
Neurulation01:30

Neurulation

47.8K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
47.8K
Epigenetic Regulation01:37

Epigenetic Regulation

4.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.3K
Epigenetic Regulation01:46

Epigenetic Regulation

34.6K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.6K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.3K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulatory logic underlying neural crest contributions to the head versus the heart.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Placode-derived orphan chemokine CXCL14 is critical for proper chick trigeminal ganglion formation.

Developmental biology·2026
Same author

Neural crest gene regulatory networks as drivers of development, diversification and disease.

Nature reviews. Molecular cell biology·2026
Same author

High-sensitivity in situ detection of Sox21 reveals transcript asymmetry from the zygote stage.

Developmental biology·2026
Same author

Running to Their Fates: Neural Crest and Placode Migratory Behavior and Cell Fate Decisions.

Cold Spring Harbor perspectives in biology·2025
Same author

Core microRNAs regulate neural crest delamination and condensation in the developing trigeminal ganglion.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Apr 20, 2026

Dissection of Xenopus laevis Neural Crest for in vitro Explant Culture or in vivo Transplantation
09:07

Dissection of Xenopus laevis Neural Crest for in vitro Explant Culture or in vivo Transplantation

Published on: March 4, 2014

14.0K

Epigenetic regulation in neural crest development.

Na Hu1, Pablo H Strobl-Mazzulla2, Marianne E Bronner1

  • 1Division of Biology and Biological Engineering, 139-74, California Institute of Technology, Pasadena, CA 91125, USA.

Developmental Biology
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Neural crest cells are vital for embryonic development, forming diverse tissues. Epigenetic regulation increasingly appears critical for controlling neural crest development and related diseases.

Keywords:
DevelopmentEpigeneticNeural crest

More Related Videos

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
09:03

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

23.7K
Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
12:48

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube

Published on: June 2, 2012

18.1K

Related Experiment Videos

Last Updated: Apr 20, 2026

Dissection of Xenopus laevis Neural Crest for in vitro Explant Culture or in vivo Transplantation
09:07

Dissection of Xenopus laevis Neural Crest for in vitro Explant Culture or in vivo Transplantation

Published on: March 4, 2014

14.0K
Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
09:03

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

23.7K
Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
12:48

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube

Published on: June 2, 2012

18.1K

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Cell Biology

Background:

  • Neural crest cells are multipotent and migratory, essential for vertebrate embryonic development.
  • They originate from the dorsal neural tube and differentiate into various cell types, including the peripheral nervous system and craniofacial structures.
  • While transcription factors and signaling molecules are well-known regulators, epigenetic mechanisms are emerging as key players.

Purpose of the Study:

  • To summarize neural crest formation processes.
  • To highlight the role of epigenetic regulation in neural crest specification, migration, and differentiation.
  • To discuss the involvement of epigenetic factors in neural crest-related birth defects and diseases.

Main Methods:

  • Literature review and synthesis of existing research on neural crest development.
  • Focus on studies investigating epigenetic modifications (e.g., DNA methylation, histone modifications) in neural crest cells.
  • Analysis of data linking epigenetic dysregulation to neural crest-associated pathologies.

Main Results:

  • Epigenetic mechanisms fine-tune gene expression essential for neural crest cell fate decisions.
  • Aberrant epigenetic regulation contributes to developmental abnormalities and diseases affecting neural crest derivatives.
  • Specific epigenetic marks are associated with distinct stages of neural crest development.

Conclusions:

  • Epigenetic regulation is a fundamental layer of control in neural crest development, complementing genetic and signaling pathways.
  • Understanding these epigenetic mechanisms offers potential therapeutic targets for neural crest-related disorders.
  • Further research into the dynamic epigenetic landscape of neural crest cells is warranted.