Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

1.4K
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.4K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

134.9K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
134.9K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

7.2K
7.2K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.3K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.3K
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

2.3K
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
2.3K
Neurotransmitters01:30

Neurotransmitters

9.8K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychedelics: Future Therapeutics in Major Depression?

Advances in experimental medicine and biology·2026
Same author

Efficacy, Safety, and Tolerability of Psychedelics in Treatment-Resistant Depression (TRD).

Advances in experimental medicine and biology·2024
Same author

A new approach to 'on-demand' treatment of lifelong premature ejaculation by treatment with a combination of a 5-HT<sub>1A</sub> receptor antagonist and SSRI in rats.

Frontiers in neuroscience·2023
Same author

Pharmacological Studies on the Role of 5-HT<sub>1</sub> <sub>A</sub> Receptors in Male Sexual Behavior of Wildtype and Serotonin Transporter Knockout Rats.

Frontiers in behavioral neuroscience·2020
Same author

The Effect of Food on the Pharmacokinetics of Buspirone After Single Administration of a Sublingual Testosterone and Oral Buspirone Combination Tablet in Healthy Female Subjects.

Sexual medicine·2020
Same author

Translational Studies in the Complex Role of Neurotransmitter Systems in Anxiety and Anxiety Disorders.

Advances in experimental medicine and biology·2020

Related Experiment Video

Updated: Apr 20, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

9.4K

Serotonin: a never-ending story.

Berend Olivier1

  • 1Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences & Brain Center Rudolf Magnus, Utrecht University, Universiteitsweg 99, 3584CG Utrecht, The Netherlands; Department of Psychiatry, Yale University School of Medicine, New Haven, USA.

European Journal of Pharmacology
|December 3, 2014
PubMed
Summary
This summary is machine-generated.

Serotonin influences mood, anxiety, and behavior. Research over 40 years explored its role in psychiatric conditions, developing animal models and novel psychotropic drugs like fluvoxamine.

Keywords:
AggressionAnxietyDepressionFluvoxamineSSRISerotonin

More Related Videos

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

15.6K
A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

3.9K

Related Experiment Videos

Last Updated: Apr 20, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
08:49

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

9.4K
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

15.6K
A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

3.9K

Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Serotonin is an ancient neurotransmitter with widespread effects on central nervous system functions.
  • These functions include mood, anxiety, stress, aggression, feeding, cognition, and sexual behavior.

Purpose of the Study:

  • To outline the author's 40-year contributions to understanding serotonin's role in psychiatric conditions.
  • To detail the development of animal models and novel drugs for depression, anxiety, and other disorders.

Main Methods:

  • Development of animal models for psychiatric diseases.
  • Drug discovery and development, including selective serotonin reuptake inhibitors (SSRIs) and other psychotropic agents.
  • Utilizing translational animal models to investigate brain mechanisms in health and disease.

Main Results:

  • Identification of serotonin's significant role in mood, anxiety, stress, aggression, and sexual behavior.
  • Successful development of innovative psychotropic drugs such as fluvoxamine, eltoprazine, and flesinoxan.
  • Advancement in understanding the neurobiological mechanisms underlying psychiatric disorders.

Conclusions:

  • The research highlights the critical role of the serotonergic system in various CNS functions and psychiatric disorders.
  • A 40-year focus on industrial and translational research has led to significant advancements in drug discovery for mental health conditions.
  • Continued investigation into translational models is crucial for uncovering new therapeutic concepts for brain disorders.