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Published on: March 3, 2021
Sarcomeric protein isoform transitions in cardiac muscle: a journey to heart failure
Zhiyong Yin1, Jun Ren2, Wei Guo3
1Animal Science, College of Agriculture and Natural Resources, University of WY, Laramie WY82071, USA; Department of Cardiology, Xi Jing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Abstract:
Sarcomeric protein isoforms are mainly governed by alternative promoter-driven expression, distinct gene expression, gene mutation and alternative mRNA splicing. The transitions of sarcomeric proteins have been implicated to play a role in the onset and development of human heart failure. In this mini-review, we summarized isoform transitions of several most widely examined sarcomeric proteins including myosin, actin, troponin, tropomyosin, titin and myosin binding protein-C, and the consequence of these abnormal isoform transitions. Even though the isoform transitions of sarcomeric proteins have been described in individual sarcomeric protein reviews, no concise summary of these results has been presented previously. This review is intended to fill this gap and discuss possible future perspectives.
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