Related Experiment Video
Updated: Apr 20, 2026
09:54
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
2.5K
Lung donor treatment protocol in brain dead-donors: A multicenter study.
Eduardo Miñambres1, Jose Miguel Pérez-Villares2, Mario Chico-Fernández3
1Service of Intensive Care, University Hospital Marqués de Valdecilla-IDIVAL, Santander.
Summary
Implementing an intensive lung donor management protocol significantly increased lung procurement rates, more than doubling the number of lung transplants performed. This protocol enhances lung donation without negatively impacting early recipient survival or primary graft dysfunction rates.
Area of Science:
- Transplantation research
- Organ donation
- Critical care medicine
Background:
- Lung transplantation is limited by donor organ availability.
- Previous research showed an intensive lung donor-treatment protocol increased lung procurement.
- This study aimed to validate the protocol across different transplant centers.
Purpose of the Study:
- To validate an intensive lung donor-treatment protocol in Spanish hospitals.
- To assess the protocol's impact on lung donor rates and transplant outcomes.
- To determine if the protocol is effective in centers with and without established lung transplant programs.
Main Methods:
- A quasi-experimental study compared lung donor rates before and after protocol implementation.
- Six Spanish hospitals participated, using donors after brain death (DBDs).
- Lung donor selection criteria remained constant; recipient outcomes (early survival, PGD) were tracked.
Main Results:
- The lung donation rate more than doubled, increasing from 13% to 27.3% after protocol implementation (p < 0.001).
- The number of retrieved lungs, transplanted grafts, and performed transplants more than doubled.
- No significant differences were observed in early recipient survival (87.6% vs. 84.5%) or primary graft dysfunction rates.
Conclusions:
- The intensive lung donor-treatment protocol effectively increases lung procurement rates.
- The protocol facilitates a higher volume of lung transplants.
- Lung transplantation outcomes, including early survival and PGD, are not compromised by this protocol.
