Enalapril attenuates glomerular hyperfiltration following a meat meal

Area of Science:

• Nephrology
• Pharmacology

Background:

• Glomerular filtration rate (GFR) increases postprandially after a meat meal.
• Enalapril reduces glomerular capillary pressure in animal models of renal failure.

Purpose of the Study:

• To investigate if enalapril attenuates the renal response to a meat meal in healthy humans.
• To assess the effect of enalapril on postprandial hyperfiltration.

Main Methods:

• Twelve healthy volunteers participated in a crossover study.
• Participants consumed a standardized meat meal on two separate occasions: with and without prior enalapril intake.
• Creatinine clearance and mean arterial pressure were measured before and after the meal.

Main Results:

• A meat meal significantly increased creatinine clearance in healthy volunteers.
• Enalapril intake resulted in a lower mean increase in creatinine clearance compared to the control day (14.0% vs. 21.0%).
• Mean arterial pressure was lower both before and after the meal in the enalapril group.

Conclusions:

• Enalapril blunts the postprandial hyperfiltration response to a meat meal in healthy individuals.
• The findings suggest a role for angiotensin-converting enzyme inhibitors in modulating meal-induced renal hemodynamics.