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Intraventricular lymphoplasmacyte-rich meningioma: a case report
Yu-Bo Wang1, Wen-Jun Wang, Song-Bai Xu
1First Hospital of Jilin University, Department of Neurosurgery, Changchun, Jilin, P.R. China.
Abstract:
Lymphoplasmacyte-rich meningioma (LPM) is one of the rarest variants of meningioma and those LPMs that arise in the intraventricular space are even rarer. LPMs are classified as grade I (benign) tumors with a low proliferative rate and diagnosis is made through the histological identification of high numbers of inflammatory cells (lymphocytes and plasma cells) in the resected tumor tissue. In the current case, magnetic resonance imaging of a 37-year-old woman who presented at our neurosurgery department following a generalized tonic-clonic seizure revealed a partially mortified intraventricular mass, which had caused pronounced peritumoral edema and had a relatively rough surface. Surgical resection was performed. Histological analysis revealed large numbers of inflammatory cells, confirming the diagnosis of LPM, but also indicated that the lesion was positive for the proliferation marker Ki-67. Follow-up magnetic resonance imaging 3 months after surgery revealed no residual tumor or recurrence.
Insights
A rare intraventricular lymphoplasmacyte-rich meningioma (LPM) was surgically removed from a 37-year-old woman. Histology confirmed LPM, showing a positive Ki-67 proliferation marker, with no recurrence at follow-up.
Area of Science:
- Neuro-oncology
- Surgical Pathology
Background:
- Lymphoplasmacyte-rich meningioma (LPM) is a rare variant of meningioma, with intraventricular occurrence being exceptionally infrequent.
- Typically classified as World Health Organization (WHO) grade I (benign), LPMs are characterized by a high infiltrate of lymphocytes and plasma cells.
Observation:
- A 37-year-old female presented with a generalized tonic-clonic seizure, leading to the discovery of an intraventricular mass via magnetic resonance imaging.
- The mass exhibited features of partial mortification, significant peritumoral edema, and a rough surface.
Findings:
- Surgical resection and subsequent histological analysis confirmed the diagnosis of LPM.
- Despite the benign classification, the tumor tested positive for the proliferation marker Ki-67.
- Post-operative imaging at 3 months showed no evidence of residual tumor or recurrence.
Implications:
- This case highlights the importance of thorough histological examination, including proliferation markers, even in typically benign tumor variants.
- The findings contribute to the understanding of intraventricular LPMs, emphasizing the need for careful surgical management and follow-up.
- Further research may elucidate the clinical significance of Ki-67 positivity in LPMs.
