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Updated: Apr 20, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

859

Therapeutic strategies of diabetic nephropathy: recent progress and future perspectives

Meng Lv1, Zhuo Chen1, Gaoyun Hu1

  • 1Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Central South University, 410013 Changsha, Hunan, China.

Drug Discovery Today
|December 3, 2014
PubMed

Insights

Diabetic nephropathy (DN) treatment is challenging, as risk factor control is insufficient. This review covers small molecules targeting DN pathogenesis like oxidative stress, inflammation, and fibrosis for future drug discovery.

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic nephropathy (DN) is a major diabetes complication with high mortality.
  • Current risk factor control is inadequate for managing DN progression.
  • DN involves complex pathogeneses including oxidative stress, inflammation, and fibrosis.

Purpose of the Study:

  • To summarize the pathogenesis of diabetic nephropathy.
  • To review small molecules targeting DN pathogenesis in preclinical and clinical studies.
  • To discuss novel anti-DN agents and future research directions.

Main Methods:

  • Literature review of DN pathogenesis.
  • Analysis of small molecules investigated for DN treatment in animal models and clinical trials.
  • Synthesis of current research and future perspectives on anti-DN drug discovery.

Main Results:

  • DN pathogenesis involves multiple interconnected pathways.
  • Several small molecules show potential in targeting these pathways.
  • Animal models and clinical trials provide insights into therapeutic efficacy.

Conclusions:

  • Comprehensive targeting of DN pathogenesis is crucial for effective treatment.
  • Small molecules offer promising therapeutic strategies for DN.
  • Further research is needed to develop novel anti-DN agents and prevention methods.

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