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Updated: Apr 20, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Cell-laden microfibers for bottom-up tissue engineering.

Hiroaki Onoe¹, Shoji Takeuchi¹

¹Institute of Industrial Science, The University of Tokyo, Japan; Takeuchi Biohybrid Innovation Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology (JST), Japan.

Drug Discovery Today

|December 3, 2014

Summary

This summary is machine-generated.

Cell-laden microfibers (CLMs) are versatile building blocks for bottom-up tissue engineering. This review explores CLM fabrication, culture, and applications in 3D tissue construction, drug testing, and implantation.

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Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Bottom-up tissue engineering uses cellular constructs for in vitro 3D tissue reconstruction.
Cell-laden microfibers (CLMs) are ideal building blocks due to their resemblance to native tissue structures.

Purpose of the Study:

To review current techniques for forming CLMs.
To summarize cell culture conditions for CLMs.
To discuss applications of CLMs in tissue engineering and beyond.

Main Methods:

Literature review of CLM fabrication techniques.
Analysis of cell culture methods for microfibers.
Synthesis of CLM applications in various fields.

Main Results:

CLMs offer a promising approach for creating organized 3D tissues.
Established methods exist for CLM formation and culture.
CLMs have potential in 3D tissue construction, drug testing models, and in vivo applications.

Conclusions:

CLM technology is advancing bottom-up tissue engineering.
Further research can overcome current challenges and expand CLM applications.
CLMs hold significant promise for future biomedical innovations.