Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 20, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

18.5K

Improving the predictive value of interventional animal models data.

Caroline J Zeiss1

  • 1Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06520, USA.

Drug Discovery Today
|December 3, 2014
PubMed
Summary

Animal models for chronic diseases show promise, but translation to humans is challenging. A network-based review of Alzheimer's disease research found repeatable positive outcomes for some interventions and mechanisms across species, aiding in silico bias reduction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishment of a laboratory mouse model to study <i>Borrelia miyamotoi</i> infection and disease.

Frontiers in immunology·2026
Same author

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories.

Journal of anatomy·2026
Same author

Neuropathology and Biomarker Correlates of Late Onset Alzheimer's Disease in Aged Old World Monkeys.

Toxicologic pathology·2025
Same author

An Introduction to the Society of Toxicologic Pathology's 44th Annual Symposium on Toxicologic Neuropathology: Basics and Beyond.

Toxicologic pathology·2025
Same author

Potential for Early Diagnosis of Leptospirosis in Experimentally Infected Rhesus Macaques Based on Detection of Leptospiral Virulence-Modifying Protein Exotoxin Antigen and Antibody.

The American journal of tropical medicine and hygiene·2025
Same author

Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C.

PLoS biology·2025

Area of Science:

  • Neuroscience
  • Pharmacology
  • Translational Medicine

Background:

  • The animal model paradigm faces challenges in translating findings to chronic diseases.
  • Alzheimer's disease research heavily relies on animal models, with limited success in human clinical trials.
  • Over 75% of animal studies report positive outcomes, suggesting potential bias.

Purpose of the Study:

  • To assess the repeatability of outcomes across species, interventions, and mechanisms using a network-based method.
  • To identify reliable findings from animal models that can inform human studies.
  • To evaluate the impact of potential confounders like strain background.

Main Methods:

  • A network-based approach was employed to analyze outcomes from animal studies.

More Related Videos

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.9K
Partial Heterotopic Hindlimb Transplantation Model in Rats
06:19

Partial Heterotopic Hindlimb Transplantation Model in Rats

Published on: June 9, 2021

3.5K

Related Experiment Videos

Last Updated: Apr 20, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

18.5K
Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.9K
Partial Heterotopic Hindlimb Transplantation Model in Rats
06:19

Partial Heterotopic Hindlimb Transplantation Model in Rats

Published on: June 9, 2021

3.5K
  • Interventions and mechanisms were assessed for cross-species repeatability.
  • Data from Alzheimer's disease animal models were specifically reviewed.

    • Main Results:

    • Over 75% of animal studies reported improved outcomes, with strain background identified as a confounder.
    • Only 5% of interventions were tested across species or in three or more animal models.
    • Donepezil, memantine, and exercise showed positive outcomes across species.
    • Repeatable positive outcomes in animals were found for the amyloid hypothesis and three other mechanisms.

    Conclusions:

    • A network-based approach can help identify reliable findings and reduce bias in animal studies.
    • Specific interventions (donepezil, memantine, exercise) and mechanisms (amyloid hypothesis) show cross-species translational potential.
    • Further research should focus on interventions with demonstrated cross-species repeatability to improve translational success.