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Haemophilus influenzae Genome Database (HIGDB): a single point web resource for Haemophilus influenzae

Rayapadi G Swetha1, Dinesh Kumar Kala Sekar2, Sudha Ramaiah1

  • 1Medical & Biological Computing Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India.

Computers in Biology and Medicine
|December 3, 2014
PubMed

Insights

The Haemophilus influenzae Genome Database (HIGDB) provides a centralized resource for H. influenzae data. This new database offers comprehensive genomic and proteomic information for this significant bacterial pathogen.

Area of Science:

  • Microbiology
  • Bioinformatics
  • Genomics

Background:

  • Haemophilus influenzae is a major cause of pneumonia, bacteraemia, and meningitis globally.
  • Despite being the first bacterium sequenced, a dedicated database for H. influenzae was lacking.

Purpose of the Study:

  • To develop a comprehensive and exclusive database for Haemophilus influenzae.
  • To consolidate diverse H. influenzae data into a single, accessible platform.

Main Methods:

  • Data storage and management using MySQL.
  • Web interface development with PERL modules, Ajax, and JavaScript.
  • Hosting on a Solaris server.

Main Results:

  • The HIGDB contains data on 42,741 proteins, 18,077 genes, and 10 whole genome sequences.
  • Includes 284 3D protein structures and features like Motif search and GBrowse.
  • Freely accessible at http://bioserver1.physics.iisc.ernet.in/HIGDB/.

Conclusions:

  • HIGDB serves as a unified access point for bacteriological, clinical, genomic, and proteomic data.
  • Enables identification of DNA motifs and comparative sequence analysis across H. influenzae strains.
Abstract

Keywords:
AnnotationDatabaseGenomeHaemophilus influenzaeResistance

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