Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

266
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
266
Liver Physiology01:30

Liver Physiology

4.5K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
4.5K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

365
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
365
Hepatitis01:25

Hepatitis

66
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
66
Proteomics01:33

Proteomics

10.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
10.3K
Protein Networks02:26

Protein Networks

3.0K
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Performance of Microvascular Imaging for Detecting Histologically Confirmed Liver Fibrosis in Autoimmune Hepatitis: Comparison with Transient Elastography and Serum Biomarkers.

Diagnostics (Basel, Switzerland)·2026
Same author

Ultrasound Characteristics of Budd-Chiari Syndrome: A Multicenter Analysis.

Digestive diseases (Basel, Switzerland)·2026
Same author

Evaluation of image quality in five different handheld ultrasound devices and analysis of various impact factors.

Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2026
Same author

Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).

Human genomics·2026
Same author

Molecular characterization of cell decay in inflammation and topological assignment of released cfDNA for integrative laboratory and radiological outcome assessment.

Frontiers in cellular and infection microbiology·2026
Same author

Medium distances to specialized care models at tertiary hospitals and socioeconomic neighborhood-related factors do not influence the quality of care for patients with liver cirrhosis.

European journal of gastroenterology & hepatology·2025

Related Experiment Video

Updated: Apr 20, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

934

Bioinformatics and database resources in hepatology.

Andreas Teufel1

  • 1Department of Medicine I, University Medical Center, Regensburg, Germany.

Journal of Hepatology
|December 3, 2014
PubMed
Summary

High-throughput technologies increase molecular data in hepatology. This review summarizes publicly available bioinformatics databases to aid liver disease research.

Keywords:
BioinformaticsComputational biologyDatabaseGeneticsHBVHCCHCVNAFLDNASHProteomicsToxic liver diseaseViral hepatitis

More Related Videos

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

4.3K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.3K

Related Experiment Videos

Last Updated: Apr 20, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

934
Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

4.3K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.3K

Area of Science:

  • Biomedical Research
  • Hepatology
  • Bioinformatics

Background:

  • High-throughput technologies have increased molecular data in hepatology.
  • Large-scale analyses are increasingly stored in diverse bioinformatics databases.
  • These repositories are essential for molecular hepatology research.

Purpose of the Study:

  • To summarize publicly available bioinformatics databases for liver disease research.
  • To facilitate access to these valuable resources for researchers.
  • To highlight the growing importance of data repositories in hepatology.

Main Methods:

  • Literature review of publicly available bioinformatics databases.
  • Categorization of databases based on scope and specialization.
  • Synthesis of information on database accessibility and utility.

Main Results:

  • A wide range of bioinformatics databases support liver disease research.
  • Databases vary in scope, from general disease information to specialized hepatology data.
  • Many valuable databases remain underutilized due to limited awareness.

Conclusions:

  • Publicly available databases are crucial for advancing molecular hepatology.
  • Increased awareness and accessibility of these resources are needed.
  • This review serves as a guide to essential bioinformatics tools for liver research.