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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
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Poststroke depression and its multifactorial nature: results from a prospective longitudinal study.
A De Ryck1, E Fransen2, R Brouns3
1Department of Nursing and Midwifery Sciences, Faculty of Medicine and Health Sciences, University of Antwerp, Belgium; Department of Neurology and Memory Clinic, ZiekenhuisNetwerk Antwerpen (ZNA) Middelheim and Hoge Beuken, Belgium.
Journal of the Neurological Sciences
|December 3, 2014
Summary
Poststroke depression (PSD) affects over 20% of stroke survivors long-term, influenced by stroke severity, disability, and relational problems. Continuous monitoring is crucial for managing this dynamic condition.
Area of Science:
- Neurology
- Psychiatry
- Epidemiology
Background:
- Poststroke depression (PSD) significantly impairs functional recovery and quality of life in stroke survivors.
- Understanding the prevalence and risk factors of PSD is critical for effective patient management.
Purpose of the Study:
- To determine the prevalence of PSD at multiple time points (1, 3, 6, 12, and 18 months) poststroke.
- To identify demographic, clinical, and psychosocial risk factors associated with PSD.
Main Methods:
- A prospective, longitudinal study including 201 stroke patients.
- Assessment of PSD using the Cornell Scale for Depression (CSD) and Montgomery and Åsberg Depression Rating Scale (MADRS).
- Analysis of potential risk factors including stroke severity, functional and cognitive outcomes, and psychosocial factors.
Main Results:
- PSD prevalence ranged from 19.8% to 28.3% across the 18-month study period.
- Significant associations found between PSD and stroke severity, physical disability, cognitive impairment, and poorer stroke outcomes.
- Relational problems (OR=3.09) and apraxia were key risk factors, while aphasia was significant early poststroke.
Conclusions:
- PSD is a dynamic and multifactorial condition with evolving risk factors.
- Long-term monitoring and support for stroke patients and caregivers are essential.
- Clinicians must consider the complex nature of PSD in patient care.
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