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A feature analysis of lower solubility proteins in three eukaryotic systems

Razvan F Albu1, Gerard T Chan1, Mang Zhu1

  • 1Department of Biochemistry and Molecular Biology and Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC, V6T 1Z4 Canada.

Journal of Proteomics
|December 3, 2014
PubMed
Summary

Researchers identified common traits of low solubility proteins across yeast, human, and mouse cells. These proteins are typically longer, less abundant, and possess more disordered regions, linking them to functional aggregates.

Keywords:
Computational biologyFunctional aggregationLow solubility proteinsMass spectrometryProteomicsProteostasis

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