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Updated: Apr 20, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

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Inhaled formulations and pulmonary drug delivery systems for respiratory infections

Qi Tony Zhou1, Sharon Shui Yee Leung1, Patricia Tang1

  • 1Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia.

Advanced Drug Delivery Reviews
|December 3, 2014
PubMed

Insights

Inhaled antimicrobial therapies offer targeted delivery for respiratory infections, reducing systemic side effects. Advanced inhaler technologies are crucial for combating drug-resistant bacteria.

Area of Science:

  • Pulmonary Medicine
  • Pharmacology
  • Biotechnology

Background:

  • Respiratory infections are a significant global health concern, often managed with systemic antimicrobial drugs.
  • Systemic administration of high-dose antimicrobials can cause severe adverse effects, necessitating alternative delivery methods.
  • There is a critical need for advanced strategies to combat respiratory infections, especially those caused by multi-drug resistant bacteria.

Purpose of the Study:

  • To explore the potential of inhaled antimicrobial formulations for targeted drug delivery to the airways.
  • To highlight recent technological advancements in inhaler devices for improved antimicrobial therapy.
  • To address the demand for novel strategies against multi-drug resistant respiratory pathogens.

Main Methods:

  • Review of recent technological advances in nebulizers and dry powder inhalers for drug delivery.
  • Discussion of particle engineering and intelligent device design for high-dose antibiotic delivery.
  • Analysis of the challenges and opportunities in developing inhaled antimicrobial therapies.

Main Results:

  • Newer mesh nebulizers offer improved aerosolization efficiency and reduced drug residue compared to traditional jet nebulizers.
  • Dry powder inhalers, utilizing novel particle engineering, are suitable for high-dose antibiotic delivery.
  • Technological progress supports the development of effective inhaled antimicrobial treatments.

Conclusions:

  • Inhaled formulations provide targeted delivery of antimicrobials to the airways, minimizing systemic exposure and adverse effects.
  • Advanced inhaler technologies are vital for effective treatment of respiratory infections, particularly against multi-drug resistant bacteria.
  • Further development of advanced formulation strategies is essential to combat the growing threat of respiratory 'super bugs'.
Keywords:
Dry powder inhalerInhaled antibioticsLiposomesNanoparticlesNebulisationParticle engineeringPharmaceutical aerosolPolymeric particles

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