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Bilateral breast cancer.

R A Pomerantz1, T Murad, J R Hines

  • 1Department of Surgery, Northwestern University Medical School, Chicago, Illinois.

The American Surgeon
|July 1, 1989
PubMed
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Bilateral breast cancer is a significant clinical issue. Multicentric histology increases contralateral breast cancer risk, supporting aggressive treatment approaches for better survival outcomes.

Area of Science:

  • Oncology
  • Clinical Medicine

Background:

  • The clinical significance of bilateral breast cancer remains debated.
  • Understanding risk factors for metachronous, contralateral breast cancer is crucial.

Purpose of the Study:

  • To identify clinical and pathological factors associated with an increased risk of metachronous, contralateral breast cancer.
  • To evaluate the survival outcomes for patients diagnosed with bilateral breast cancer.

Main Methods:

  • Retrospective review of 187 patients treated for primary breast cancer.
  • Analysis of various clinical and pathological variables, including patient demographics, medical history, tumor characteristics, and treatment details.
  • Life table survival analysis was employed.

Main Results:

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  • The incidence of metachronous, contralateral breast cancer was 11.8%.
  • Multicentric histology was the only factor significantly associated with bilateral breast cancer.
  • Five-year survival following treatment for metachronous, contralateral cancer was 59%.

Conclusions:

  • Bilateral breast cancer represents a significant clinical problem.
  • Histology characterized by multicentricity is linked to a higher incidence of bilateral breast cancer.
  • Favorable survival rates justify an aggressive management strategy for bilateral breast cancer.