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Management of choroidal metastases
P Jardel1, W Sauerwein2, T Olivier3
1Department of Radiation Oncology, University Hospital, 2 rue de la Milétrie, 86000 Poitiers, France.
Cancer Treatment Reviews
|December 3, 2014
Summary
Choroidal metastases (CM) are common in cancer patients and often cause vision loss. Radiotherapy is effective for symptom relief and local control, though long-term outcomes require further study.
Area of Science:
- Ophthalmology
- Oncology
- Radiation Oncology
Background:
- Choroidal metastases (CM) are the most frequent malignant intraocular tumors, affecting 4-12% of cancer patients.
- CM can lead to significant visual deterioration and vary in presentation from disseminated to isolated disease.
Purpose of the Study:
- To review the multidisciplinary management of choroidal metastases.
- To discuss technical aspects of radiotherapy for CM.
Main Methods:
- A systematic literature review was conducted from 1974 to 2014.
Main Results:
- Breast and lung carcinomas are the most common primary tumors for CM.
- External beam radiotherapy (30Gy/10fx or 40Gy/20fx) achieves 80% complete response and 57-89% visual acuity improvement.
- Chemotherapy and targeted therapies show promising response rates.
Conclusions:
- Radiotherapy offers rapid symptom relief, excellent local control, and functional outcomes for CM.
- Long-term toxicity data is limited due to poor prognosis; further research on long-term outcomes is needed.
- Systemic therapies may suit pauci-symptomatic cases, while radiotherapy is crucial for symptomatic CM; focalized radiation is an option for isolated CM in select patients.
Keywords:
Breast cancerChoroidal metastasisLung cancerRadiotherapyTreatmentTumor responseVisual acuityMore Related Videos
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