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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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Clinical applicability of reticulated platelets
Luci Maria SantAna Dusse1, Letícia Gonçalves Freitas1
1Department of Clinical and Toxicological Analysis, Faculty of Pharmacy-Universidade Federal de Minas Gerais, Brazil.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 3, 2014
Summary
Reticulated platelets (RPs) reflect bone marrow platelet production. Measuring RPs helps assess conditions like thrombocytopenia and thrombocytosis, aiding in diagnosis and treatment monitoring.
Area of Science:
- Hematology
- Clinical Pathology
Background:
- Reticulated platelets (RPs) are immature platelets with high RNA content.
- RPs are larger and more prone to thrombus formation than mature platelets.
Purpose of the Study:
- To review and establish the clinical significance of reticulated platelets.
- To explore the diagnostic utility of RPs in various hematological conditions.
Main Methods:
- Compilation of existing literature evaluating reticulated platelets.
- Analysis of studies focusing on RP measurement and clinical correlation.
Main Results:
- RP levels correlate with platelet production: increasing with higher production and decreasing with lower production.
- RP measurement aids in assessing thrombocytopenia by differentiating between bone marrow production issues and peripheral destruction.
Conclusions:
- Reticulated platelets serve as a valuable indicator of bone marrow platelet production.
- RPs show promise in evaluating idiopathic thrombocytopenia, chemotherapy effects, stem cell transplant recovery, and thrombocytosis.
- Further clinical studies are needed to fully establish the significance of RPs in diverse clinical scenarios.
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