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Existence of a polar digitalis-like factor in mammalian hypothalamus
1Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Biochemical and Biophysical Research Communications
|June 30, 1989
Abstract:
We were able to partially purify a polar digitalis-like factor from rat and bovine hypothalami based on the capacity to inhibit [3H]ouabain binding to intact human erythrocytes. This factor was characterized in reference to the digitalis-like factor that we have isolated and reported on. Hypothalamic factor shared digitalis-like activities and physicochemical properties with the one derived from human urine and mammalian plasma. These findings strongly suggest that a polar digitalis-like factor identical to the circulatory factor does exist in mammalian hypothalamus.