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Updated: Apr 20, 2026
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Renal arcuate vein microthrombi-associated AKI
Andrew Redfern1, Huda Mahmoud1, Tom McCulloch2
1Department of Renal Medicine, Royal Derby Hospital, Derby, United Kingdom;
Clinical Journal of the American Society of Nephrology : CJASN
|December 3, 2014
Summary
Young adults developed acute kidney injury (AKI) with unusual kidney biopsy findings after alcohol consumption. The cause remains unexplained, highlighting the need for further research into this specific AKI presentation.
Area of Science:
- Nephrology
- Toxicology
- Pathology
Background:
- Presents six young adults with stages 2-3 acute kidney injury (AKI), hematuria, and unexplained renal biopsy findings.
- Patients consumed alcohol prior to admission, with symptoms including flank or lower back pain.
Observation:
- Renal biopsies revealed microthrombi in arcuate veins and localized inflammation at the corticomedullary junction.
- Imaging studies were unremarkable, and extensive investigations for thrombophilia, drugs, and alcohol yielded no definitive cause.
Findings:
- All patients recovered to baseline renal function within 6-60 days with supportive care, without requiring renal replacement therapy (RRT).
- Histopathologic changes were unique and not previously reported, with no similar cases identified by the UK National Poisons Information Centre.
Implications:
- Suggests a potential link between alcohol consumption and specific, unexplained renal histopathology leading to AKI.
- Emphasizes the need for increased clinical awareness and further studies to elucidate the pathophysiology of this AKI subtype.
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