Related Experiment Video
Updated: Apr 20, 2026

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
Published on: July 31, 2013
Glycine gated spiking inhibitory postsynaptic membrane at the synaptic cleft
1Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.
Background:
Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.
Purpose:
The objective of this work is to develop a simple analog circuit model that can simulate the function of neurotransmitter glycine gated ion channels of postsynaptic membrane at the synaptic cleft.
Methods:
In this paper, Glycine sensitive ENFET is incorporated into the Hodgkin-Huxley (H-H) circuit model of the postsynaptic membrane at the synaptic cleft.
Results:
Simulation of the circuit model yields an output representing the membrane potential of the synaptic region. Simulation is performed in MATLAB environment for inhibitory action of synapses.
Conclusion:
This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.
More Related Videos
Related Concept Videos
Excitatory and Inhibitory Effects of Neurotransmitters
Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Postsynaptic Potential (PSP)
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Integration of Synaptic Events

