Related Experiment Video

Updated: Apr 20, 2026

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

2.0K

Microvillus inclusion disease associated with necrotizing enterocolitis in a premature infant

Ersin Sayar1, Salih Kalay2, Aygen Yilmaz1

  • 1Department of Pediatric Gastroenterology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

AJP Reports
|December 3, 2014
PubMed

Insights

Microvillus inclusion disease, a rare congenital diarrheal disorder, can be associated with necrotizing enterocolitis in premature infants. Early recognition is crucial for managing this life-threatening condition.

Area of Science:

  • Gastroenterology
  • Pediatric Pathology
  • Neonatology

Background:

  • Microvillus inclusion disease (MVID) is a rare congenital diarrheal disorder.
  • It is characterized by distinct inclusion bodies within the intestinal epithelium.
  • MVID is a life-threatening condition with limited reported cases.

Observation:

  • This report details a case of MVID in a premature infant.
  • The infant also presented with necrotizing enterocolitis.
  • This association highlights a critical clinical observation.

Findings:

  • The co-occurrence of MVID and necrotizing enterocolitis in a premature infant is documented.
  • This case underscores the potential for severe gastrointestinal complications.

Implications:

  • Clinicians should maintain a high index of suspicion for necrotizing enterocolitis in infants diagnosed with MVID.
  • Awareness of this association is vital, particularly when risk factors for necrotizing enterocolitis are present.
  • Prompt diagnosis and management are essential for improving patient outcomes.
Keywords:
intractable diarrheamicrovillus inclusion diseasenecrotizing enterocolitispremature

More Related Videos

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

2.9K
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

4.3K

Related Concept Videos

Microvilli00:55

Microvilli

Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances.
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity...
11.7K
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
19
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.3K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
70
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.7K