Related Experiment Video
Updated: Apr 20, 2026

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
Published on: June 14, 2020
Hypertrophic tonsils in sickle cell patients in ghana
Background:
Sickle-cell disease (SCD) is one of the commonest genetic blood disorders in the world and principally affects people of African, Mediterranean and Asian origin. It is an established fact that SCD patients often present with hypertrophic tonsils and as such Objective: The aim of this study was to determine the prevalence of hypertrophic tonsils in sickle cell disease patients in Ghana.
Method:
This is a case control prospective study involving sickle cell disease-SS patients aged between 2 and 13 years and 40 aged-matched controls who met the inclusion criteria at the Komfo Anokye Teaching Hospital, Ghana. The participants were examined using head lamp and a Breuning's tongue depressor. The tonsils sizes were estimated using the Brodsky's criteria.
Result:
This study showed 93.1% of the patients presenting with various degrees of tonsillar hypertrophy. Thirty-four percent presented with grade 3 Brodsky's hypertrophy, 24. 6% with grade 2, 20.1% with grade 4 and 14.2% with grade 1. Only 6.9% presented with Brodsky grade 0.
Conclusion:
The prevalence of hypertrophic tonsils is very high among sickle cell patients in Kumasi, Ghana.
Related Concept Videos
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Tonsillitis II: Management
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Sputum Studies II: Culture and Sensitivity
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...

