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Updated: Apr 20, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
The prognostic significance of troponin elevation in patients with sepsis: a meta-analysis
Olusegun Sheyin1, Oluwaseun Davies1, Wenlan Duan1
1Department of Medicine, Harlem Hospital Center, in affiliation with the College of Physicians and Surgeons of Columbia University, New York, USA.
Objective:
To confirm the association between troponin elevation in patients with sepsis and mortality.
Background:
Cardiac troponins are sensitive and specific biomarkers of myocardial injury; however their prognostic significance in patients with sepsis is still debated.
Methods:
PubMed and Ovid MEDLINE were searched for original articles using MeSH terms 'Troponin' and 'Sepsis.' Studies reporting on mortality in patients with sepsis, severe sepsis or septic shock who had troponin measured were eligible for inclusion. Meta-analysis was conducted with Review Manager.
Results:
Seventeen studies, with total sample size of 1857 patients were included. Elevated troponin was found to be significantly associated with mortality (Risk ratio: 1.91; 95% CI: 1.65-2.22; p < 0.05).
Conclusions:
Troponin elevation in patients with sepsis confers poorer prognosis and is a predictor of mortality. Further studies are needed to see if more aggressive treatment of this subset of patients, or utilizing new therapeutic approaches will improve mortality.
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