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A Contusion Model of Severe Spinal Cord Injury in Rats
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Top ten research priorities for spinal cord injury

Joost J van Middendorp1, Harriet Allison2, Katherine Cowan3

  • 1Stoke Mandeville Spinal Foundation, National Spinal Injuries Centre, Stoke Mandeville Hospital, Buckinghamshire NHS Healthcare Trust, Buckinghamshire, HP21 8AL, UK; Harris Manchester College, University of Oxford, Oxford, UK.

The Lancet. Neurology
|December 3, 2014
PubMed
Abstract

No abstract available in PubMed .

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Spinal Cord Injury ll: Pathophysiology01:14

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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Secondary Spinal Cord Injury llI: Pathophysiology01:25

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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