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Antipsychotic induced metabolic changes & treatment response: a prospective study
Eesha Sharma1, Ganesan Venkatasubramanian2, Shivarama Varambally1
1The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore 560029, India.
Asian Journal of Psychiatry
|December 3, 2014
Summary
Early changes in appetite and triglyceride levels predict antipsychotic treatment response in patients with psychosis. These metabolic side effects may serve as early indicators of treatment efficacy.
Area of Science:
- Psychiatry
- Metabolic Medicine
- Pharmacology
Background:
- Metabolic side effects of antipsychotics are linked to treatment non-compliance and morbidity.
- Existing research suggests a correlation between metabolic changes and antipsychotic treatment response, but systematic investigation is limited.
- This study explores the association between metabolic alterations and treatment outcomes in psychosis.
Purpose of the Study:
- To investigate the predictive value of early metabolic changes for antipsychotic treatment response.
- To examine the relationship between appetite, lipid profiles, and treatment efficacy in patients with psychosis.
- To identify potential early biomarkers for antipsychotic treatment success.
Main Methods:
- A prospective, naturalistic, trans-diagnostic study involving 100 patients with psychosis initiating antipsychotic monotherapy.
- Assessment included the Brief Psychiatric Rating Scale (BPRS), appetite, anthropometric measurements, and serum lipid/glucose profiles at baseline and follow-ups (2-4 and 8-12 weeks).
- Forward stepwise multiple linear regression was used to analyze predictors of treatment response (BPRS score reduction).
Main Results:
- Early increases in appetite and triglyceride levels at 2-4 weeks predicted 26% of the variance in treatment response at the first follow-up.
- At 8-12 weeks, early increases in triglyceride levels predicted 16% of the variance in treatment response.
- No significant differences were observed in baseline characteristics between patients who completed follow-ups and those who dropped out.
Conclusions:
- Early changes in appetite and triglyceride levels are significant predictors of antipsychotic treatment response.
- These findings suggest that metabolic side effects could serve as early indicators of treatment efficacy.
- Further research is warranted to explore the interaction between metabolic pathways, psychotic illnesses, and antipsychotic mechanisms of action.
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