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A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds

Preetpal Singh Sidhu1, Qibing Zhou2, Umesh R Desai1

  • 1Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, United States; Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23219, United States.

Bioorganic & Medicinal Chemistry Letters
|December 3, 2014
PubMed

Keywords:
AnticoagulationFactor XIaSulfationThrombin

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