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Updated: Apr 20, 2026

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
Published on: January 26, 2013
A competitive cell fate switch
Arnaldo Carreira-Rosario1, Michael Buszczak1
1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Abstract:
Whereas tissue development and homeostasis depend on stem cell self-renewal and differentiation, the mechanisms that balance these processes remain incompletely understood. Pan et al. (2014) now show that competitive protein-protein interactions between Bam and COP9 signalosome components regulate cell fate decisions within the Drosophila ovarian germline stem cell lineage.
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